Efficient synthesis of cyclic amidine-based fluorophores<i>via</i>6π-electrocyclic ring closure
Guofeng Li, Man Zhao, Junqiu Xie, Ying Yao, Lingyun Mou, Xiaowei Zhang, Xiaomin Guo, Wangsheng Sun, Zheng Wang, Jiecheng Xu, Jianzhong Xue, Tao Hu, Ming Zhang, Min Li, Liang Hong
Abstract
-sulfonyl triazoles and arylamines. The photophysical properties of cyclic amidine fluorophores have been studied in detail and have shown good properties of a large Stokes shift, pH insensitivity, low cytotoxicity and higher photostability, which have great potential for biological imaging. Furthermore, this novel fluorophore was successfully applied to the localization of the NK-1 receptor in living systems.
Topics & Concepts
KetenimineAmidineRing (chemistry)ImineClosure (psychology)Electrocyclic reactionChemistryCombinatorial chemistryComputational chemistryStereochemistryOrganic chemistryCatalysisMarket economyEconomicsCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions