Gold-Catalyzed Synthesis of Icetexane Cores: Short Synthesis of Taxamairin B and Rosmaridiphenol
Quynh Thuy Le, Lihui Guo, Seung Lyeol Lee, Junseong Lee, Chang Ho Oh
Abstract
We report the short synthesis of two natural products, rosmaridiphenol and taxamairin B, from key intermediates 5a and 5b, which were prepared from enynals 8a and 9b, respectively, by using a gold-catalyzed cyclization reaction. This approach can be widely applied in the synthesis of [6,7,6]-fused tricyclic compounds found in many icetexane diterpenoids.
Topics & Concepts
ChemistryCatalysisTricyclicCombinatorial chemistryStereochemistryOrganic chemistrySynthetic Organic Chemistry MethodsMarine Sponges and Natural ProductsTraditional and Medicinal Uses of Annonaceae