Synaptic plasticity during systems memory consolidation
Akihiro Goto
Abstract
After learning, memory is initially encoded in the hippocampus but subsequently stabilized in other brain regions such as the cortex for long-lasting storage. This process is known as systems memory consolidation, and its cellular mechanism has long been a fundamental question. Synaptic plasticity is the major cellular mechanism underlying learning and memory, and is therefore considered a key function in the process of systems memory consolidation. Therefore, many studies have aimed to establish a causal link between synaptic plasticity in the brain and memory-associated behaviors. In this review, I discuss the various lines of research showing the function of synaptic plasticity, mainly in the hippocampus and cortex during memory consolidation.