Photo-induced mitochondrial DNA damage and NADH depletion by –NO<sub>2</sub> modified Ru(<scp>ii</scp>) complexes
Shuang Qi, Zhihui Jin, Jian Yao, Yuanjun Hou, Chao Li, Yao Zhao, Xuesong Wang, Qianxiong Zhou
Abstract
Two mitochondria-localized Ru(ii) complexes with photo-labile ligands were reported to exert one- and two-photon activatable anticancer activity through a dual-function mechanism, i.e. mitochondrial DNA covalent binding after photo-induced ligand dissociation and photo-catalyzed NADH depletion, thus displaying good activity towards cisplatin-resistant cancer cells under both normoxic and hypoxic conditions.
Topics & Concepts
Mitochondrial DNADNAChemistryDNA damageMitochondrionBiophysicsBiochemistryBiologyGeneMetal complexes synthesis and propertiesMolecular Sensors and Ion DetectionSupramolecular Chemistry and Complexes