Esketamine increases neurotransmitter releases but simplifies neurotransmitter networks in mouse prefrontal cortex
Ye Wang, Yunyun Zhang, Kai Wang, Zhenghua Zhu, Dan Wang, Qianzi Yang, Hailong Dong
Abstract
In this study, we found that esketamine significantly increased the cortical concentration of multiple neurotransmitters in mice. However, esketamine dynamically simplified the overall network of cortical neurotransmitters at different behavioral states during the perianesthesia period. The concentration of 5-HT in the medial prefrontal cortex (mPFC) was highly correlated with the esketamine-increased gamma oscillation. These findings suggested that the transformation of the neurotransmitter network rather than the concentrations of neurotransmitters could be more indicative of the consciousness shift during esketamine anesthesia.
Topics & Concepts
NeurotransmitterPrefrontal cortexNeuroscienceMicrodialysisKetamineChemistryNeuromodulationGlutamate receptorDopamineAnesthesiaPsychologyCentral nervous systemMedicineReceptorCognitionBiochemistryNeuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms