Stabilization but No Functional Influence of HIF-1α Expression in the Intestinal Epithelium during Salmonella Typhimurium Infection
Laura Robrahn, Aline Dupont, Sandra Jumpertz, Kaiyi Zhang, Christian H. Holland, Joël Guillaume, Sabrina Rappold, Johanna Roth, Vuk Cerovic, Julio Sáez-Rodríguez, Mathias W. Hornef, Thorsten Cramer
Abstract
Hypoxia-inducible transcription factor 1 (HIF-1) has been shown to enhance microbial killing and ameliorate the course of bacterial infections. While the impact of HIF-1 on inflammatory diseases of the gut has been studied intensively, its function in bacterial infections of the gastrointestinal tract remains largely elusive.
Topics & Concepts
BiologyHIF1AIntestinal epitheliumSalmonella entericaMicrobiologyEpitheliumSalmonellaProinflammatory cytokineCXCL2Intestinal mucosaSalmonella infectionTranscription factorImmunologyCancer researchImmune systemInflammationChemokineGeneBacteriaMedicineInternal medicineGeneticsAngiogenesisChemokine receptorCancer, Hypoxia, and MetabolismCancer Research and TreatmentsRNA modifications and cancer