Identification and Verification of the Prodigiosin Biosynthetic Gene Cluster (BGC) in Pseudoalteromonas rubra S4059
Xiyan Wang, Thomas Isbrandt, Emil C. Ørsted, Jette Melchiorsen, Thomas Ostenfeld Larsen, Sheng‐Da Zhang, Lone Gram
Abstract
Pigmented Pseudoalteromonas strains are renowned for their production of secondary metabolites, and genome mining has revealed a high number of biosynthetic gene clusters (BGCs) for which the chemistry is unknown. Identification of those BGCs is a prerequisite for linking products to gene clusters and for further exploitation through heterologous expression.
Topics & Concepts
ProdigiosinIdentification (biology)Gene clusterBiologyGeneGeneticsComputational biologyPseudoalteromonasBotanySerratia marcescensEscherichia coli16S ribosomal RNAMicrobial Metabolism and ApplicationsMicrobial Natural Products and BiosynthesisPharmacological Effects of Natural Compounds