Identification of PI3K/HDAC Dual-targeted inhibitors with subtype selectivity as potential therapeutic agents against solid Tumors: Building HDAC6 potency in a Quinazolinone-based PI3Kδ-selective template
Zhi Li, Can Zhao, Ge He, Yujie Wang, Yujie Wang, Yang Wang, Yang Wang, Xiaodong Ma
Topics & Concepts
ChemistryPI3K/AKT/mTOR pathwayHDAC6PotencyCancer researchCytotoxicityIC50PharmacologyIn vitroBiochemistrySignal transductionBiologyHistone deacetylaseHistoneGeneHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisProtein Degradation and Inhibitors