Multi-scale modeling of folic acid-functionalized TiO<sub>2</sub>nanoparticles for active targeting of tumor cells
Edoardo Donadoni, Paulo Siani, Giulia Frigerio, Cristiana Di Valentin
Abstract
NP and the presence of PEG spacers impact on the actual exposure of the ligands, especially by affecting the extent of FA-FA intermolecular interactions, which are detrimental for the targeting ability of FA towards the folate receptor. This analysis provides a solid and rational basis for experimentalists to define the optimal FA density and the more appropriate mode of anchoring to the carrier, according to the final purpose of the nanoconjugate.
Topics & Concepts
Folic acidNanoparticleNanotechnologyMaterials scienceCombinatorial chemistryChemistryMedicineInternal medicineNanoparticle-Based Drug DeliveryGraphene and Nanomaterials ApplicationsNanoparticles: synthesis and applications