Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors
Peng-Chao Huo, Qing Hu, Sheng Shu, Qihang Zhou, Rong-Jing He, Jie Hou, Xiao‐Qing Guan, Dong‐Zhu Tu, Xu-Dong Hou, Peng Liu, Nan Zhang, Zhiguo Liu, Guang‐Bo Ge
Topics & Concepts
ChalconeChemistryPancreatic lipaseEnzymeLipaseActive siteStereochemistryIC50HydrolysisMixed inhibitionChalcone synthaseBiochemistryDocking (animal)Lead compoundNon-competitive inhibitionIn vitroBiosynthesisNursingMedicinePharmacology and Obesity TreatmentNatural Antidiabetic Agents StudiesEnzyme Catalysis and Immobilization