Palladium-Catalyzed Four-Component Radical Cascade Carbonylation Access to 2,3-Disubstituted Benzofuran Derivatives
Ming Li, Dong‐Yu Miao, Fan Gao, Shan-Mei Xu, Shun‐Xi Li, Dong‐Ping Chen, Yi‐Feng Qiu, Zheng‐Jun Quan, Xi‐Cun Wang, Yong‐Min Liang
Abstract
Multicomponent radical tandem reactions have emerged as a crucial technique for synthesizing complex molecules in organic chemistry. In this study, we report a palladium-catalyzed four-component difluoroalkylative carbonylation of enynes and ethyl difluoroiodoacetate. This transformation proceeds through a multistep sequential reaction that introduces reactive difluoro and carbonyl groups while constructing the benzofuran skeleton. Moreover, a variety of valuable 2,3-disubstituted benzofuran derivatives were obtained in respectable yields with excellent functional group compatibility.
Topics & Concepts
ChemistryCarbonylationPalladiumBenzofuranCatalysisCascadeComponent (thermodynamics)Combinatorial chemistryOrganic chemistryMedicinal chemistryCarbon monoxideChromatographyThermodynamicsPhysicsFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions