A synthetic human 3D in vitro lymphoid model enhancing B-cell survival and functional differentiation
Maaike V.J. Braham, Rob van Binnendijk, Anne‐Marie Buisman, Reina E. Mebius, Jelle de Wit, Cécile A. C. M. van
Abstract
B-cells was observed. The formation of large B-cell clusters indicates the formation of GC-like structures. In conclusion, a well-characterized and controllable hydrogel-based human 3D lymphoid model is presented that supports enhanced B-cell survival, proliferation, differentiation, and antibody production.
Topics & Concepts
Germinal centerCD19Stromal cellB cellCell biologyChemistryCD40Naive B cellCellular differentiationIn vitroAntibodyBiologyImmunologyBiochemistryCancer researchGeneCytotoxic T cellT-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Cell Function and Interaction