Kidney Drug Transporters in Pharmacotherapy
Joanna Łapczuk-Romańska, Maria Droździk, Maria Droździk, Stefan Oswald, Marek Droździk, Marek Droździk
Abstract
The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug-drug interactions, as well as constituting direct drug targets. The above aspects of kidney transport proteins are discussed in the review.
Topics & Concepts
PharmacotherapyDrugPharmacologyTransporterKidneyMedicineChemistryInternal medicineBiochemistryGeneDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesBipolar Disorder and Treatment