Neuregulin-1 compensates for endothelial nitric oxide synthase deficiency
Hadis Shakeri, Jente R. A. Boen, Sofie De Moudt, Jhana O. Hendrickx, Arthur Leloup, Griet Jacobs, Guido R.Y. De Meyer, Gilles W. De Keulenaer, Pieter‐Jan Guns, Vincent F. M. Segers
Abstract
ECs compensate for eNOS deficiency by increasing the secretion of NRG1. NRG1 administration prevents cardiac and renal hypertrophy and fibrosis caused by ANG II infusion and eNOS deficiency. NRG1 expression is regulated by miR-134.
Topics & Concepts
Endothelial nitric oxide synthaseNitric oxide synthaseNitric oxideChemistryNeuregulinInternal medicineMedicineBiochemistrySignal transductionEnosNitric Oxide and Endothelin EffectsCardiovascular Function and Risk FactorsCardiac Ischemia and Reperfusion