Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells
Anna Śledzińska, Maria Vila de Mucha, Katharina Bergerhoff, Alastair Hotblack, Dafne Franz Demane, Ehsan Ghorani, Ayse U. Akarca, Maria A. V. Marzolini, Isabelle Solomon, Frederick Arce Vargas, Martin Pulé, Masahiro Ono, Benedict Seddon, George Kassiotis, Charlotte E. Ariyan, Thomas Korn, Teresa Marafioti, Graham M. Lord, Hans J. Stauss, Richard G. Jenner, Karl S. Peggs, Sergio A. Quezada
Abstract
T cells and offer a pathway to enhancement of anti-tumor activity through their manipulation.
Topics & Concepts
Cytotoxic T cellBiologyFunction (biology)Cell biologyInterleukin 2ImmunologyImmune systemGeneticsIn vitroImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses