Independent bi-reversible reactions and regulable FRET efficiency achieving real-time visualization of Cys metabolizing into SO<sub>2</sub>
Tao Li, Fangjun Huo, Jianbin Chao, Caixia Yin
Abstract
In this work, we synthesized an independent bi-reversible reaction sensor BPC for simultaneously detecting cysteine (Cys) and sulfur dioxide (SO2), showing multi-fluorescence signal modes due to the regulable FRET efficiency, and finally achieving real-time process visualization of Cys metabolizing into SO2 in subcellular organelles and tumors.
Topics & Concepts
Förster resonance energy transferVisualizationCysteineChemistryProcess (computing)OrganelleSulfurBiophysicsComputer scienceBiochemistryBiologyData miningFluorescenceOrganic chemistryPhysicsEnzymeQuantum mechanicsOperating systemSulfur Compounds in BiologyMolecular Sensors and Ion DetectionNanoplatforms for cancer theranostics