Different mechanisms of drug resistance to hypomethylating agents in the treatment of myelodysplastic syndromes and acute myeloid leukemia
Kristína Šimoničová, Ľuboš Janotka, Helena Kavcová, Zdena Sulová, Albert Breier, Lucia Messingerová
Topics & Concepts
Myelodysplastic syndromesAzacitidineMyeloid leukemiaDrug resistanceHypomethylating agentPharmacologyDeoxycytidine kinaseMedicineDecitabineCytidineMechanism (biology)DrugLeukemiaCancer researchBiologyDeoxycytidineImmunologyInternal medicineCancerDNA methylationBone marrowGeneticsGeneBiochemistryEpistemologyEnzymeGene expressionGemcitabinePhilosophyAcute Myeloid Leukemia ResearchPneumocystis jirovecii pneumonia detection and treatmentHIV/AIDS drug development and treatment