Investigations of the reactivity, stability and biological activity of halido (NHC)gold(<scp>i</scp>) complexes
Sina Katharina Goetzfried, Paul Kapitza, Caroline Marie Gallati, Anna Nindl, Monika Cziferszky, Martin Hermann, Klaus Wurst, Brigitte Kircher, Ronald Gust
Abstract
The significance of the halido ligand (Cl − , Br − , I − ) in (NHC)gold( i ) complexes in ligand exchange reactions, including the ligand scrambling to the bis(NHC)gold( i ) complex 5, was evaluated by HPLC and discussed in relation to the biological activity in A2780 cell lines.
Topics & Concepts
ChemistryThioredoxin reductaseLigand (biochemistry)NucleophileReactivity (psychology)IodideAcetonitrileMedicinal chemistryGold CompoundsCarbeneStereochemistryThiocyanateEnzymeCombinatorial chemistryThioredoxinOrganic chemistryBiochemistryReceptorCatalysisAlternative medicinePathologyMedicineMetal complexes synthesis and propertiesRedox biology and oxidative stressMetal-Catalyzed Oxygenation Mechanisms