Macrocyclic Peptides that Selectively Inhibit the <i>Mycobacterium tuberculosis</i> Proteasome
Hao Zhang, Hao-Chi Hsu, Shoshanna C. Kahne, Ryoma Hara, Wenhu Zhan, Xiuju Jiang, Kristin Burns-Huang, Tierra Ouellette, Toshihiro Imaeda, Rei Okamoto, Masanori Kawasaki, Mayako Michino, Tzu‐Tshin Wong, Akinori Toita, Takafumi Yukawa, Francesca Moraca, Jérémie Vendôme, Priya Saha, Kenjiro Sato, Kazuyoshi Aso, John D. Ginn, Peter T. Meinke, Michael A. Foley, Carl Nathan, K. Heran Darwin, Huilin Li, Gang Lin
Abstract
dose dependently led to the accumulation of Pup-tagged GFP that is degradable but resistant to depupylation and death of nonreplicating Mtb under nitrosative stress. These results suggest that compounds of this class have the potential to develop as anti-TB therapeutics.
Topics & Concepts
Mycobacterium tuberculosisProteasomeChemistryTuberculosisMicrobiologyBiochemistryBiologyMedicinePathologyBiochemical and Molecular ResearchUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis