Cascade Cyclizations Triggered by Photochemically Generated Carbamoyl Radicals Derived from Alkyl Amines
Ganesh Chandra Upreti, Tavinder Singh, Divakar Chaudhary, Anand Singh
Abstract
We report on a visible light-mediated cascade carbamoylation/cyclization of acrylamides using dihydropyridyl carbamoyl donors derived from alkyl amines. Diversely selected acrylamides including 2-cyano- N -arylacrylamides, indolyl- and benzimidazolyl acrylamides, and 2-alkynyl- N -aryl acrylamides participate in this reaction, providing products in good yields. The highlights of this photochemical method include the application of alkyl amine-derived carbamoyl donors, peroxide-free reaction conditions, and a broad scope.
Topics & Concepts
AlkylAmine gas treatingChemistryArylRadicalCascadeHydrogen peroxideCombinatorial chemistryOrganic chemistryPhotochemistryChromatographyRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods