Metal‐free Decarboxylative Annulation of 2‐Aryl‐2‐isocyano‐acetates with Aryldiazonium Salts: General Access to 1,3‐Diaryl‐1,2,4‐triazoles
Yu‐Ting Tian, Fa‐Guang Zhang, Jing Nie, Chi Wai Cheung, Jun‐An Ma
Abstract
Abstract Isocyanoacetates are versatile substrates for the synthesis of heterocyclic compounds, but the concomitant decarboxylation remains rare. Herein we report a decarboxylative annulation reaction of 2‐aryl‐2‐isocyanoacetates with aryldiazonium salts. This metal‐free, base‐promoted protocol allows for the access to a broad collection of 1,3‐diaryl‐1,2,4‐triazoles, including chiral triazole‐based binaphthalene ligands, drug mimics, and synthetic intermediates of druglike molecules. magnified image
Topics & Concepts
ChemistryAnnulationArylDecarboxylationCombinatorial chemistryMoleculeOrganic chemistryCatalysisAlkylCatalytic C–H Functionalization MethodsClick Chemistry and ApplicationsMulticomponent Synthesis of Heterocycles