Enrichment of sulphate-reducers and depletion of butyrate-producers may be hyperglycaemia signatures in the diabetic oral microbiome
Camilla Pedrosa Vieira Lima, Daniela Corrêa Grisi, Maria do Carmo Machado Guimarães, Loise Pedrosa Salles, Paula de Castro Kruly, Thuy Do, Luiz Gustavo dos Anjos Borges, Nailê Damé‐Teixeira
Abstract
Objectives: This study aimed to investigate oral microbial signatures associated with hyperglycaemia, by correlating the oral microbiome with three glycaemic markers. Potential association between clinical parameters and oral bacterial taxa that could be modulating the hyperglycaemic microbiome was also explored. Methods: gene was amplified from total salivary DNA, and amplicons were sequenced (Illumina MiSeq). Results: was clustered in a negative association with caries-associated and butyrate-producing bacteria. Conclusion: The salivary microbiome is shaped by systemic hyperglycaemia, as well as changes in the salivary pH, which may be linked to local hyperglycaemia. The enrichment of predictive biomarkers of gut dysbiosis in the salivary microbiome can reflect its capacity for impairment of hyperglycaemia.