The vascular endothelial growth factor trap aflibercept induces vascular dysfunction and hypertension via attenuation of eNOS/NO signaling in mice
Zhichao Dong, Ming‐Ming Wu, Yun‐Long Zhang, Qiushi Wang, Chen Liang, Xiao Yan, Lei‐Xin Zou, Chen Chen, Xiao Han, Bo Zhang, Zhi‐Ren Zhang
Topics & Concepts
AfliberceptEnosEndothelial dysfunctionEndocrinologyInternal medicineMedicineProtein kinase BPharmacologyNitric oxideOxidative stressVascular endothelial growth factorVascular endothelial growth factor ANitric oxide synthaseSignal transductionChemistryBiochemistryChemotherapyVEGF receptorsBevacizumabNitric Oxide and Endothelin EffectsAngiogenesis and VEGF in CancerEicosanoids and Hypertension Pharmacology