Quantitative analysis of an impact of P-glycoprotein on edoxaban's disposition using a human physiologically based pharmacokinetic (PBPK) model
Takafumi Kato, Tsuyoshi Mikkaichi, Yasushi Yoshigae, Noriko Okudaira, Takako Shimizu, Takashi Izumi, Shuichi Ando, Yoshiaki Matsumoto
Topics & Concepts
Physiologically based pharmacokinetic modellingPharmacokineticsPharmacologyP-glycoproteinEffluxEdoxabanChemistryTransporterAbsorption (acoustics)DispositionMedicineInternal medicineBiochemistryAntibioticsAtrial fibrillationWarfarinMultiple drug resistancePsychologyGeneDabigatranPhysicsSocial psychologyAcousticsDrug Transport and Resistance MechanismsGastroesophageal reflux and treatmentsAntibiotics Pharmacokinetics and Efficacy