Teadenol A in microbial fermented tea acts as a novel ligand on GPR120 to increase GLP-1 secretion
Tomotaka Nagasawa, Kanji Ishimaru, Shigeki Higashiyama, Yoichiro Hama, Susumu Mitsutake
Abstract
concentration in 293T cells, and these effects were completely dependent on GPR120 expression. Our results suggest that teadenol A binds and activates GPR120 directly. Furthermore, teadenol A enhanced the secretion of GLP-1 from intestinal endocrine STC-1 cells. GLP-1 suppresses appetite and increases insulin secretion, exhibiting anti-diabetic effects. GPR120/GLP-1 signaling is attracting attention as a potential target for pharmaceuticals against type 2 diabetes. Our results suggest that teadenol A is a key molecule in post-fermented tea responsible for beneficial effects on metabolic syndrome.
Topics & Concepts
FermentationHyperlipidemiaFood scienceSecretionChemistryBusinessBiologyBiochemistryDiabetes mellitusEndocrinologyTea Polyphenols and EffectsPhytoestrogen effects and researchNatural product bioactivities and synthesis