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Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks

Jacob W. Freimer, Oren Shaked, Sahin Naqvi, Nasa Sinnott-Armstrong, Arwa S. Kathiria, Christian M. Garrido, Amy F. Chen, Jessica T. Cortez, William J. Greenleaf, Jonathan K. Pritchard, Alexander Marson

2022Nature Genetics88 citationsDOIOpen Access PDF

Topics & Concepts

BiologyGeneGene regulatory networkComputational biologyGeneticsImmune systemRegulation of gene expressionRegulator geneRegulatory sequenceGene expressionT-cell and B-cell ImmunologyImmune Cell Function and InteractionSingle-cell and spatial transcriptomics
Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks | Litcius