Role of Autophagy Pathway in Parkinson’s Disease and Related Genetic Neurological Disorders
Christos Themistokleous, Enrico Bagnoli, Ramaa Parulekar, Miratul M. K. Muqit
Abstract
The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in the elimination of damaged mitochondria by autophagy (mitophagy) has provided unprecedented understanding of the mechanistic pathways underlying Parkinson's disease (PD). We provide a comprehensive overview of the general importance of autophagy in Parkinson's disease and related disorders of the central nervous system. This reveals a critical link between autophagy and neurodegenerative and neurodevelopmental disorders and suggests that strategies to modulate mitophagy may have greater relevance in the CNS beyond PD.
Topics & Concepts
MitophagyParkinAutophagyPINK1Parkinson's diseaseUbiquitin ligaseLRRK2NeuroscienceBiologyDiseaseUbiquitinMitochondrionCell biologyMedicineGeneticsGeneApoptosisPathologyAutophagy in Disease and TherapyParkinson's Disease Mechanisms and TreatmentsLysosomal Storage Disorders Research