A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19
Tao Chen, Yuxin Lin, Yan Zha, Ying Sun, Jinxiu Tian, Zhiying Yang, Shanwen Lin, Fuxun Yu, Zi‐Sheng Chen, Bo‐Hua Kuang, Jin-Ju Lei, Yingjie Nie, Yonghao Xu, Dongbo Tian, Yingzi Li, Bin Yang, Qiang Xu, Li Yang, Nanshan Zhong, Meizhen Zheng, Yimin Li, Jincun Zhao, Xiangyan Zhang, Lin Feng
Abstract
Overproduction of cytokine interleukin-6 (IL-6) is a hallmark of severe COVID-19 and is believed to play a critical role in exacerbating the excessive inflammatory response. Polymorphisms in IL-6 account for the variability of IL-6 expression and disparities in infectious diseases, but its contribution to the clinical presentation of COVID-19 has not been reported.
Topics & Concepts
HaplotypeCTCFSingle-nucleotide polymorphismAlleleBiologyLocus (genetics)SNPGeneticsExpression quantitative trait lociImmunologyEnhancerGenotypeTranscription factorGeneInflammasome and immune disordersinterferon and immune responsesCOVID-19 Clinical Research Studies