Dynamic and Thermodynamic Bounds for Collective Motor-Driven Transport
Matthew Leighton, David A. Sivak
Abstract
Molecular motors work collectively to transport cargo within cells, with anywhere from one to several hundred motors towing a single cargo. For a broad class of collective-transport systems, we use tools from stochastic thermodynamics to derive a new lower bound for the entropy production rate which is tighter than the second law. This implies new bounds on the velocity, efficiency, and precision of general transport systems and a set of analytic Pareto frontiers for identical motors. In a specific model, we identify conditions for saturation of these Pareto frontiers.
Topics & Concepts
Entropy productionWork (physics)Pareto principleStatistical physicsMolecular motorEntropy (arrow of time)Computer sciencePhysicsUpper and lower boundsMathematical optimizationThermodynamicsMathematicsMaterials scienceNanotechnologyMathematical analysisAdvanced Thermodynamics and Statistical Mechanicsstochastic dynamics and bifurcationSpectroscopy and Quantum Chemical Studies