Synthesis and Biological Evaluation of 4′-Substituted Kaempfer-3-ols
Sugyeom Kim, Yu Li, Lin Lin, Peyton R. Sayasith, Ariel T. Tarr, Eric B. Wright, Sharia Yasmin, Deborah A. Lannigan, George A. O’Doherty
Abstract
The synthesis of two series of five kaempfer-3-ols was described. The first set all have a C-3 hydroxyl group and the second has a carboxymethoxy ether at the C-3 position. Both series have variable substitution at the C-4′ position (i.e., OH, Cl, F, H, OMe). Both kaempferols and carboxymethoxy ethers were evaluated for their ability to inhibit ribosomal s6 kinase (RSK) activity and cancer cell proliferation.
Topics & Concepts
ChemistryEtherStereochemistryPosition (finance)Cell growthChemical synthesisKinaseBiochemistryIn vitroOrganic chemistryEconomicsFinanceMetal complexes synthesis and propertiesCrystal structures of chemical compoundsSynthesis of Organic Compounds