Yield of a public health screening of children for islet autoantibodies in Bavaria, Germany
A Ziegler, Kimberly Kick, Ezio Bonifacio, F Haupt, M Hippich, D Dunstheimer, M Lang, O Laub, K Warncke, K Lange, R Assfalg, M Jolink, C Winkler, Peter Achenbach
Abstract
This study aimed to determine the prevalence of pre-symptomatic T1D in young children participating in a public health screening program for islet autoantibodies and the risk for progression to clinical T1D in children carrying multiple autoantibodies. On screening, 0.03% were found to have clinical T1D. Of the 0.31% who were found to have pre-symptomatic T1D, 24.9% developed clinical T1D during the 3-year follow-up.
Topics & Concepts
AutoantibodyIsletMedicinePediatricsPublic healthType 1 diabetesInternal medicineImmunologyDiabetes mellitusEndocrinologyInsulinPathologyAntibodyDiabetes and associated disordersPancreatic function and diabetesDiabetes Management and Research