Design, semi-synthesis and examination of new gypsogenin derivatives against leukemia via Abl tyrosine kinase inhibition and apoptosis induction
Nafia Gökçe Ulusoy, Safiye Emirdağ, Ece Sözer, Mohamed O. Radwan, Halil I. Ciftci, Mehran Aksel, Serap Şahin‐Bölükbaşı, Ali Özmen, Nurettin Yaylı, Tamer Karayıldırım, Özgen Alankuş‐Çalışkan, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita, Belgin Sever
Topics & Concepts
Chronic myelogenous leukemiaImatinibJurkat cellsK562 cellsTyrosine kinaseABLApoptosisCancer researchChemistryLeukemiaKinaseDasatinibImatinib mesylateCell cultureTyrosine-kinase inhibitorIC50PharmacologyBiologyIn vitroImmunologyMyeloid leukemiaBiochemistrySignal transductionT cellGeneticsImmune systemCancerChronic Myeloid Leukemia TreatmentsFungal Plant Pathogen ControlPI3K/AKT/mTOR signaling in cancer