Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases
Aliaa M. Mohassab, Heba A. Hassan, Dalia Abdelhamid, Ahmed M. Gouda, Bahaa G. M. Youssif, Hiroshi Tateishi, Mikako Fujita, Masami Otsuka, Mohamed Abdel‐Aziz
Topics & Concepts
ChalconeChemistryErlotinibKinaseTriazoleQuinolineEGFR inhibitorsMoietyDocking (animal)Growth inhibitionCell cultureCell growthBiochemistryCancer researchStereochemistryEpidermal growth factor receptorReceptorBiologyOrganic chemistryNursingMedicineGeneticsSynthesis and biological activityQuinazolinone synthesis and applicationsClick Chemistry and Applications