Luminescent cyclometalated platinum(<scp>ii</scp>) complexes with acyclic diaminocarbene ligands: structural, photophysical and biological properties
Mónica Martínez-Junquera, Elena Lalinde, M. Teresa Moreno, Elvira Alfaro‐Arnedo, Icíar P. López, Ignacio M. Larráyoz, José G. Pichel
Abstract
MLCT excited state. The carbene ligand does not affect the emission maxima but it produces an increase of the quantum yields in relation to the isocyanide in the precursors. In fluid solutions, the emission is not concentration-dependent, but the complexes may show aggregation induced emission as detailed for complexes 3a and 4a. In addition, cytotoxicity studies in the human cell lines A549 (lung carcinoma) and HeLa (cervix carcinoma) showed good activity for these complexes and 3a, 3b and 4a exhibit a strong effect on DNA electrophoretic mobility. To the best of our knowledge, compounds 3 and 4 represent the first examples of cycloplatinated complexes bearing acyclic diamino carbenes with antiproliferative properties.