The <i>Chlamydia trachomatis</i> Inclusion Membrane Protein CTL0390 Mediates Host Cell Exit via Lysis through STING Activation
R. Clayton Bishop, Isabelle Derré
Abstract
mutant led to reduced Golgi translocation of STING, and chemical and genetic approaches to inactivate STING revealed that STING plays a role in lysis in a CTL0390-dependent manner. Together, these results reveal a role for CTL0390 in bacterial exit via lysis at late stages of the Chlamydia developmental cycle and through STING activation.
Topics & Concepts
BiologyChlamydia trachomatisLysisIntracellular parasiteCell biologyMicrobiologyIntracellularBrefeldin ACytosolGolgi apparatusMolecular biologyVirologyBiochemistryEndoplasmic reticulumEnzymeViral Infections and Vectorsinterferon and immune responsesReproductive tract infections research