Bee bread mitigates downregulation of steroidogenic genes, decreased spermatogenesis, and epididymal oxidative stress in male rats fed with high-fat diet
Joseph Bagi Suleiman, Ainul Bahiyah Abu Bakar, Mahanem Mat Noor, Victor Udo Nna, Zaidatul Akmal Othman, Zaida Zakaria, Chinedum Eleazu, Mahaneem Mohamed
Abstract
The high-fat diet utilized in the present study induced obesity in the male rats. Bee bread supplementation mitigated impaired steroidogenesis, spermatogenesis, mating behavior, and fertility potential by counteracting the downregulation of steroidogenic genes, thus increasing testosterone levels and suppressing epididymal oxidative stress. These benefits may be due to the abundance of phenolic and flavonoid compounds in bee bread.
Topics & Concepts
Downregulation and upregulationOxidative stressSpermatogenesisEndocrinologyTestosterone (patch)Internal medicineBiologyGeneObesityMale fertilityFertilityMedicineGeneticsPopulationEnvironmental healthBee Products Chemical AnalysisInsect and Pesticide ResearchAntioxidant Activity and Oxidative Stress