Sulbactam–durlobactam: a β-lactam/β-lactamase inhibitor combination targeting <i>Acinetobacter baumannii</i>
Sarah M. McLeod, John P. O’Donnell, Navaneeth Narayanan, John Mills, Keith S. Kaye
Abstract
Sulbactam–durlobactam is a pathogen-targeted β-lactam/β-lactamase inhibitor combination that has been approved by the US FDA for the treatment of hospital-acquired and ventilator-associated bacterial pneumonia caused by susceptible isolates of Acinetobacter baumannii–calcoaceticus complex (ABC) in patients 18 years of age and older. Sulbactam is a penicillin derivative with antibacterial activity against Acinetobacter but is prone to hydrolysis by β-lactamases encoded by contemporary isolates. Durlobactam is a diazabicyclooctane β-lactamase inhibitor with activity against Ambler classes A, C and D serine β-lactamases that restores sulbactam activity both in vitro and in vivo against multidrug-resistant ABC. Sulbactam–durlobactam is a promising alternative therapy for the treatment of serious Acinetobacter infections, which can have high rates of mortality.