Sources and Methods for the Production of Xyloglucan, a Promising Stimulus-Sensitive Biopolymer: A Review
Е. О. Бахрушина, V. S. Pyzhov, Jana A. Yuntunen, A. S. Gulenkov, Shoyad D. Arislanov, К. В. Еремеева, A. V. Belyatskaya, Н. Б. Демина, I. I. Krasnyuk, I. I. Krasnyuk
Abstract
Xyloglucan is a highly promising 'green' polymer that has found its application in the food and pharmaceutical industries. Due to its molecular structure similarity to mucin, it has remarkable mucoadhesion properties, which has led to a high research interest in this excipient for the development of transmucosal delivery systems. Thermosensitivity is another promising property of xyloglucan derivatives, which is mainly exhibited by synthetic block copolymers such as pluronics and PLGA derivatives. Delivery systems whose mechanism of active ingredient release is based on temperature sensitivity are widely used in many medical fields, ranging from antitumour therapy to intranasal delivery. Thus, conducting research on the possibility of obtaining and using a new mucoadhesive, fully biocompatible and affordable polymer-xyloglucan-is a promising task.