Sulfonic Acid and Ionic Liquid Functionalized Covalent Organic Framework for Efficient Catalysis of the Biginelli Reaction
Bing‐Jian Yao, Wen-Xiu Wu, Luo‐Gang Ding, Yu‐Bin Dong
Abstract
A quinoline-linked and ionic liquid-decorated covalent organic framework was prepared by incorporation of a multicomponent Povarov reaction and postsynthetic modification. The imidazolium and sulfonic acid-decorated COF-IM-SO3H can be a highly efficient Brønsted acid catalyst to promote the Biginelli reaction under solvent-free conditions in a heterogeneous way. In addition, a scaled-up Biginelli reaction has been readily realized over a COF-IM-SO3H@chitosan aerogel-based cup reactor.
Topics & Concepts
ChemistryBiginelli reactionIonic liquidSulfonic acidQuinolineCatalysisCovalent bondCovalent organic frameworkOrganic chemistryAerogelBrønsted–Lowry acid–base theoryHeterogeneous catalysisGreen chemistryOrganocatalysisAldehydeIonic bondingChemical engineeringEnantioselective synthesisIonEngineeringMulticomponent Synthesis of HeterocyclesChemical Synthesis and ReactionsCovalent Organic Framework Applications