COVID-19: Molecular and Cellular Response

Shamila D. Alipoor, Esmaeil Mortaz, Hamidreza Jamaati, Payam Tabarsi, Hasan Bayram, Mohammad Varahram, Ian M. Adcock

2021Frontiers in Cellular and Infection Microbiology53 citationsDOI Open Access PDF

Abstract

In late December 2019, a vtiral pneumonia with an unknown agent was reported in Wuhan, China. A novel coronavirus was identified as the causative agent. Because of the human-to-human transmission and rapid spread; coronavirus disease 2019 (COVID-19) has rapidly increased to an epidemic scale and poses a severe threat to human health; it has been declared a public health emergency of international concern (PHEIC) by the World Health Organization (WHO). This review aims to summarize the recent research progress of COVID-19 molecular features and immunopathogenesis to provide a reference for further research in prevention and treatment of SARS coronavirus2 (SARS-CoV-2) infection based on the knowledge from researches on SARS-CoV and Middle East respiratory syndrome-related coronavirus (MERS-CoV).

Topics & Concepts

Coronavirus disease 2019 (COVID-19)PneumoniaPublic healthCoronavirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Middle East respiratory syndrome coronavirusBetacoronavirusTransmission (telecommunications)Atypical pneumoniaMiddle East respiratory syndrome2019-20 coronavirus outbreakPandemicVirologyMedicineCoronavirus InfectionsGlobal healthDiseaseImmunologyInfectious disease (medical specialty)OutbreakPathologyComputer scienceTelecommunicationsInternal medicineSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19