Immune responses during COVID-19 infection
Cléa Melenotte, Aymeric Silvin, Anne‐Gaëlle Goubet, Imran Lahmar, Agathe Dubuisson, Alimuddin Zumla, Didier Raoult, Mansouria Merad, Bertrand Gachot, Clémence Henon, Éric Solary, Michaëla Fontenay, Fabrice André, Markus Maeurer, Giuseppe Ippolito, Mauro Piacentini, Fu-Sheng Wang, Florent Ginhoux, Aurélien Marabelle, Guido Kroemer, Lisa Derosa, Laurence Zitvogel
Abstract
, immune responses to SARS-CoV2 sometimes derail towards inflammatory tissue damage, leading to rapid admissions to intensive care units. The lack of knowledge on mechanisms that tilt the balance between these two opposite outcomes poses major threats to many ongoing clinical trials dealing with immunostimulatory or immunoregulatory therapeutics. This review will discuss innate and cognate immune responses underlying protective or deleterious immune reactions against these pathogenic coronaviruses.