Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Julia L. Finkelstein, Amy Fothergill, Sudha Venkatramanan, Alexander J. Layden, Jennifer L. Williams, Krista S. Crider, Yan Qi
Abstract
BACKGROUND: supplementation during pregnancy may confer longer-term benefits to maternal and child health outcomes. OBJECTIVES: supplementation during pregnancy on maternal and child health outcomes. SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth's Trials Register, ClinicalTrials.gov, the World Health Organization International Clinical Trials Registry Platform (ICTRP) on 2 June 2023, and reference lists of retrieved studies. SELECTION CRITERIA: supplementation during pregnancy. DATA COLLECTION AND ANALYSIS: We used standard Cochrane methods. Four review authors independently assessed trial eligibility. Two review authors independently extracted data from included studies and conducted checks for accuracy. Three review authors independently assessed the risk of bias of the included studies using the Cochrane RoB 1 tool. We used GRADE to evaluate the certainty of evidence for primary outcomes. MAIN RESULTS: supplementation had improved expressive language domain compared to placebo (30 months, BSID-III; 1 trial; low-certainty evidence). AUTHORS' CONCLUSIONS: status, but the potential impact on longer-term clinical and functional maternal and child health outcomes has not yet been established.