Bioactive milk-derived nutrient MFG-E8 ameliorates skeletal muscle atrophy induced by mitochondria damage in aging rats via activating the MAPK/ERK signaling pathway
Kaifang Guan, Xiaolin Liu, Weihong Lu, Yuhao Mao, Yirong Mao, Ying Ma, Rongchun Wang, Qiming Li
Abstract
phase. Molecular level further proved that MFG-E8 mediated cell cycle and promoted cell proliferation by activating the MAPK/ERK signaling pathway.
Topics & Concepts
MAPK/ERK pathwayCell biologySkeletal muscleMuscle atrophyChemistryMitochondrionSignal transductionBiochemistryBiologyEndocrinologyMuscle Physiology and DisordersGenetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy