Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters
Peter J. Kilfoil, Shuyun Feng, Asser Bassyouni, Tiffany Lee, Derek J. Leishman, Dingzhou Li, David J. MacEwan, Parveen Sharma, Eric D. Watt, Stephen Jenkinson
Topics & Concepts
hERGQRS complexQT intervalInduced pluripotent stem cellMedicinePharmacologyDrug discoveryMexiletinePredictive valueDrugLong QT syndromeCardiologyComputational biologyInternal medicineBioinformaticsChemistryBiologyPotassium channelEmbryonic stem cellBiochemistryGeneCardiac electrophysiology and arrhythmiasNeuroscience and Neural EngineeringReceptor Mechanisms and Signaling