Hypoglycemic activity of <i>Codonopsis pilosula (Franch.)</i> Nannf. <i>in vitro</i> and <i>in vivo</i> and its chemical composition identification by UPLC-Triple-TOF-MS/MS
Wenjing Jia, Qimao Bi, Sirong Jiang, Jihong Tao, Liying Liu, Huilan Yue, Xiaohui Zhao
Abstract
, respectively. In addition, the CPNE could significantly decrease the postprandial blood glucose (PBG) levels in the sucrose/maltose/starch tolerance assays of diabetic mice. Furthermore, a total of 29 compounds, including 3 alkaloids, 13 phenolic acids, 8 alcohol glycosides and 5 alkynosides, were assigned based on comparison with the standards and references, as well as the analysis of main fragments. These results demonstrated that CPN could be used as an adjuvant therapy or dietary supplements to effectively control the occurrence and development of diabetes.
Topics & Concepts
In vivoChemistryIn vitroBiologyBiochemistryBiotechnologyNatural Antidiabetic Agents StudiesMedicinal Plants and Bioactive CompoundsPhytochemicals and Antioxidant Activities