Metformin and cyanidin 3-<i>O</i>-galactoside from<i>Aronia melanocarpa</i>synergistically alleviate cognitive impairment in SAMP8 mice
Haichao Wen, Hehe Tian, Chang Liu, Xiaoxu Zhang, Yao Peng, Xinquan Yang, Feng Chen, Jingming Li
Abstract
Cyanidin 3- O -galactoside (Cy3Gal) from Aronia melanocarpa and coadministration of metformin had a neuroprotective effect and alleviated cognitive impairment in the SAMP8 mice, and regulated the metabolites in feces and urine.
Topics & Concepts
MetforminUrineGalactosideChemistryPharmacologyNeuroprotectionMedicineEndocrinologyBiochemistryDiabetes mellitusEnzymeNatural Antidiabetic Agents StudiesMedicinal Plants and NeuroprotectionBiochemical effects in animals