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The dual alkylation of the C(sp<sup>3</sup>)–H bond of cyclic α-methyl-<i>N</i>-sulfonyl imines <i>via</i> the sequential condensation/hydride transfer/cyclization process

Kejin Yuan, Feng‐Ying Dong, Xiangcong Yin, Shuai‐Shuai Li, Liang Wang, Lubin Xu

2020Organic Chemistry Frontiers21 citationsDOI

Abstract

The dual alkylation of the C(sp<sup>3</sup>)–H bond of the cyclic α-methyl-<italic>N</italic>-sulfonyl imine has been achieved through the piperidine-promoted cascade condensation/[1,5]-hydride transfer/cyclization from cyclic α-methyl-<italic>N</italic>-sulfonyl imine and o-aminobenzaldehyde in trifluoroethanol.

Topics & Concepts

ChemistryAlkylationSulfonylImineHydridePiperidineMedicinal chemistryCondensationSodium hydrideOrganic chemistryCatalysisMetalThermodynamicsAlkylPhysicsSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis
The dual alkylation of the C(sp<sup>3</sup>)–H bond of cyclic α-methyl-<i>N</i>-sulfonyl imines <i>via</i> the sequential condensation/hydride transfer/cyclization process | Litcius