Binding thermodynamics and interaction patterns of human purine nucleoside phosphorylase-inhibitor complexes from extensive free energy calculations
Zhe Huai, Huaiyu Yang, Zhaoxi Sun
Topics & Concepts
Purine nucleoside phosphorylaseChemistryLigand (biochemistry)Small moleculePlasma protein bindingStereochemistryComputational chemistryPurineBiochemistryEnzymeReceptorBiochemical and Molecular ResearchEnzyme Structure and FunctionAdenosine and Purinergic Signaling