The Zinc Transporter ZnuABC Is Critical for the Virulence of Chromobacterium violaceum and Contributes to Diverse Zinc-Dependent Physiological Processes
Renato Elias Rodrigues de Souza Santos, Waldir P. da Silva Júnior, Simone Harrison, Eric P. Skaar, Walter Chazin, José F. da Silva Neto
Abstract
mouse infection model and showed low capacities to colonize the liver, grow in the presence of CP, and resist neutrophil killing. Overall, our findings demonstrate that ZnuABC is essential for C. violaceum virulence, contributing to subversion of zinc-based host nutritional immunity.
Topics & Concepts
VirulenceChromobacterium violaceumBiologyOperonMicrobiologyZincBiofilmATP-binding cassette transporterMutantQuorum sensingPermeaseBacteriaTransporterBiochemistryGeneGeneticsChemistryOrganic chemistryMicrobial Metabolism and ApplicationsBacterial biofilms and quorum sensingMedicinal Plants and Neuroprotection