Platelet membrane-coated alterbrassicene A nanoparticle inhibits calcification of the aortic valve by suppressing phosphorylation P65 NF-κB
Bingchuan Geng, Xing Chen, Jiangyang Chi, Fengli Li, Wai Yen Yim, Kan Wang, Chenghao Li, Minghui Xie, Peng Zhu, Zhengfeng Fan, Jiawei Shi, Zhengxi Hu, Yonghui Zhang, Nianguo Dong
Abstract
The establishment of im-hVICs provides a convenient cell line for the study of CAVD. Moreover, our current research highlights a novel natural compound, ABA, as a promising candidate to prevent the progression of CAVD.
Topics & Concepts
CalcificationAortic valveBone morphogenetic protein 2PhosphorylationRUNX2Cancer researchBone morphogenetic proteinCell biologyChemistryMedicinePathologyInternal medicineBiochemistryTranscription factorBiologyIn vitroGeneCardiac Valve Diseases and TreatmentsInfective Endocarditis Diagnosis and ManagementProtease and Inhibitor Mechanisms